AIM:To investigate the risk factors and long-term changes of non-arteritis anterior ischaemic optic neuropathy(NAION).

METHODS:Three hundred and sixty cases of patients with NAION in our hospital from January 2010 to Juny 2015 were used as patients group and another 400 people undergoing health examination were used as control group. The clinical data was collected. Optical coherence tomography(OCT)was performed.

RESULTS:There were significant difference on gender, history of diabetes or hypertension, arteriosclerosis history, disc area, cup area, rim area, cup/disc area ratio, horizontal cup-disc ratio, vertical cup-disc ratio, FBG and TG of two groups(P<0.05). Male, with diabetes, history of hypertension, arteriosclerosis history, disc area, cup area, rim area, cup/disc area ratio, horizontal cup-disc ratio, vertical cup-disc ratio, FBG and TG were independent risk factors of NAION. Top, nasal, below temporal side and average global retinal nerve fiber layer(RNFL)of patients with NAION at 6,12 and 18mo after the onset were significantly lower than those of control group(P<0.05). There was no significant difference between patients with different disease course(P>0.05).

CONCLUSION:Male, with diabetes, history of hypertension, arteriosclerosis history, disc area, cup area, rim area, cup/disc area ratio, horizontal cup-disc ratio, vertical cup-disc ratio, FBG and TG are independent risk factors of NAION. Long-term damage of RNFL may not aggravate.