AIM: To investigate clinical efficacy of loratadine and diclofenac sodium eye drops for allergic conjunctivitis and to improve the outcomes of patients with allergic conjunctivitis.

METHODS: The selected 154 patients(158 eyes)with allergic conjunctivitis were randomly divided into control group and observation group, 77 patients(79 eyes )in each group. Patients in control group were treated with loratadine. Patients in observation group were treated with diclofenac sodium eye drops besides loratadine. Scores on symptoms and physical signs of two groups were compared and clinical efficacy of two group was evaluated and compared.

RESULTS: Before treatments, the scores on symptoms and physical signs of two groups were not significantly different(P>0.05). After treatments,the scores of observation group on eye itching, tearing, photophobia, burning sensation and foreign body sensation were respectively 1.03±0.10, 0.83±0.10, 0.62±0.06, 0.80±0.05 and 1.10±0.09score. The scores on conjunctival congestion and edema, secretions, nipple-like follicular on palpebral conjunctiva, limbus change, corneal epithelial changes as well as eyelid and periocular edema of observation group were respectively 0.95±0.08,0.63±0.05,1.32±0.13,0.67±0.06,0.72±0.06, 0.55±0.04score.All the aspects mentioned above were lower in observation group than in control group and the differences were statistically significant(P<0.05). The effective rate and total effective rate of control group were 30.48% and 68.4% respectively, those of observation group were 50.6% and 86.1%, the differences of the two groups were statistically significant(P<0.05).

CONCLUSION: Systemic treatment of loratadine combined with local treatment of diclofenac sodium eye drops for allergic conjunctivitis can relieve the clinical signs and symptoms better, make the treatment more effective with easy drug administration, which is an effective treatment.