Myopia, especially high myopia, is one of the most important eye diseases in the world. For many years the researchers established a variety of animal models and animal experiments to explore the mechanism of development of myopia. Guinea pig is one of the most commonly used myopia models in recent years. It has obvious advantages in many aspects, and it is a kind of experimental animals which is worth to be further applied to different kinds of myopic experiments and to be studied thoroughly. This article reviews the induction methods and the forming process of the guinea pig myopia model.