Abstract:AIM:To investigate the therapeutic efficiency of preservative-free sodium hyaluronate eye drops on dry eye in juvenile myopia wearing rigid gas permeable contact lens(RGP).
METHODS:Ninety cases with dry eye related to wearing RGP in juvenile with myopia from January to May 2015 were selected. The patients aged 12.75±4.15 years old,with diopter of -3.50±1.50D as spherical equivalent and received normalized RGP. They were divided into 3 groups randomly,each group of 30 cases(60 eyes):group A used rewetting drops,1 drop each time,4 times per day; group B used preservative-free sodium hyaluronate eye drops(1g/L),1 drop each time,4 times per day; group C used rewetting drops at first, then sodium hyaluronate eye drops was used 15 minutes later.All cases had been detected and evaluated by subjective symptoms of dry eye,Schirmer I test(SⅠt),break-up time(BUT)and corneal fluorescent staining,at pre-therapy and 1, 2, 4wk of post-therapy.
RESULTS:The subjective symptoms of dry eye,corneal fluorescent staining and BUT of three groups had been obviously improved at 1wk after therapies than those before therapies(P<0.05). SⅠt of three groups hadn't shown significant differences after therapies(P>0.05).Every index of the three groups measured at 2 and 4wk after treatments had no significant differences compared to those measured at 1wk(P>0.05).There was no significant difference on subjective symptoms,SⅠt and BUT between group A and B(P>0.05),except on corneal fluorescent staining, on which group B was superior to group A and on which the difference was significant(P<0.05).Group C in improving the subjective symptoms of dry eye and corneal fluorescent staining was better than group A(P<0.05).Group C, on improving the subjective symptoms of dry eye, was better than group B(P<0.05).
CONCLUSION:Preservative-free sodium hyaluronate eye drops(1g/L)can stabilize the tear film and promote the repair of corneal epithelial defects and significantly improve dry eye symptoms and signs in juvenile myopia wearing RGP,so it has certain clinical application value.
