AIM:To retrospectively analyze the myopia progression in children after oral delivery of Difrarel for 6mo.

METHODS:Collecting myopic children aged 3～13 in our hospital from June 2012 to January 2015, 36 cases(69 eyes)included, 16 males(30 eyes)and 20 females(39 eyes). After dilated by atropine eye ointment, all cases were divided into three groups according to the spherical equivalent degree. There were 30 eyes in high myopia group(>-6.00D),24 eyes in moderate myopia group(-3.00～-6.00D)and 15 eyes in mild myopia group(<-3.00D).Meanwhile all cases divided into two groups according to the age. There were 21 eyes in preschool children group(<6 years old),48 eyes in juvenile group(≥6 years old).The spherical equivalent degree,best corrected visual acuity, axial length(AL),curvatures radius of cornea(CR), the AL/CR were self-comparative analyzed before and after 6mo of oral delivery Difrarel.

RESULTS:The spherical equivalent degree, AL and AL/CR increased in mild and moderate myopia group after oral delivery of Difrarel for 6mo, but had found statistically significant differences in moderate myopia group only(P<0.05). The spherical equivalent degree and AL increased in high myopia group also, but no change in AL/CR, and all had no significant differences in high myopia group(P>0.05). The spherical equivalent degree, AL and AL/CR increased in preschool children group and juvenile group,but only AL and AL/CR had found statistically significant differences in preschool children group(P<0.05).

CONCLUSION:Short-term oral delivery of Difrarel in children can control the progression of mild and high myopia, but have no effect on moderate myopia; and short-term oral delivery of Difrarel in children can control the progression of juvenile myopia, but have no effect on preschool myopia.