AIM:To investigate the relation of Decorin(DCN)gene and simple pathological myopia in Inner Mongolia region.

METHODS:Genomic DNA was collected from 100 control subjects and 100 patients with simple pathological myopia. The exon7 and exon8 and the flanking intron regions of DCN gene were analyzed by polymerase chain reaction(PCR)and direct sequencing. The relation of Decorin gene exon7 and exon8 with simple pathological myopia was statistically analyzed.

RESULTS:In simple pathological myopia group, 2 patients' gene mutations were identified. Both was 41775T→C,located at the flanking intron regions of exon8. No variation was found in others including control group. The gene mutation between controls and simple pathological myopia groups were not different(P>0.05).

CONCLUSION:DNC gene exon7 and exon8 mutation may not be the disease gene in this group in Inner Mongolia region.