AIM:To study the therapeutic effect of intravitreal injection of Bevacizumab combined with laser photocoagulation for diabetic macular edema.

METHODS:Sixty-nine cases(82 eyes)with diabetic macular edema in our hospital form February 2014 to March 2015 were selected and they were randomly divided into two groups(41 eyes in each group).The observation group were given the combination treatment with intravitreal injection of bevacizumab and laser photocoagulation. The control group was given the laser photocoagulation only. The best corrected visual acuity(BCVA),the central macular thickness(CMT),the results of fundus fluorescein angiography(FFA),and the intraocular pressure between two groups were observed and compared.

RESULTS:BCVA and CMT of the observation group became better at 1,3 and 6mo after treatment(P<0.05).BCVA of the control group had no changes(P>0.05)and CMT decreased at 1,3 and 6mo(P<0.05), but the result of FFA rebounded at 6mo. There were significant differences between two groups on BCVA and CMT after treatment(P<0.05). None of patients in two groups got any local or systemic complication at 1,3 and 6mo after treatment.

CONCLUSION:Intravitreal injection of bevacizumab combined with laser photocoagulation for diabetic macular edema is much more effective and has less complication.It is worth promoting in clinical application.