AIM:To investigate the morphology changes of peripapillary retinal nerve fiber layer(pRNFL)and macular ganglion cell complex(GCC)in patients with Parkinson's disease.

METHODS:Eighty eyes in 40 patients with Parkinson's disease(PD)treated in Beijing Tian Tan Hospital from July 2014 to May 2015 and 60 normal eyes in 30 patients were controlled in the study. Each section of pRNFL thickness and GCC thickness were measured by optic coherence tomography(OCT). The correlation between pRNFL and GCC of Parkinson's disease group, and the difference of pRNFL and GCC between the Parkinson's disease group and normal group were evaluated and analyzed.

RESULTS:Compared with normal group, the pRNFL thickness of superior temporal(ST), superior nasal(SN), inferior nasal(IN), temporal upper(TU), inferior temporal(IT), temporal lower(TL), average, superior and inferior section significantly decreased in Parkinson's disease group(P<0.05). The GCC thickness of average, superior and inferior significantly decreased in the Parkinson's disease group compared with normal group(P<0.05).The positive correlations were seen between the pRNFL thickness and the GCC thickness of average, superior, inferior respectively(Avg:r=0.743,P=0.01; Sup:r=0.689,P=0.01; Inf:r=0.693,P=0.01).

CONCLUSION:The pRNFL thickness and GCC thinckness are significantly thinner in patients with Parkinson's disease than those in the normal controls. Average, superior, inferior pRNFL thickness is positively correlated to average, superior, inferior GCC thickness respectively in Parkinson's disease group.