AIM:To investigate the relation of mean platelet volume(MPV), neutrophil-to-lymphocyte ratio(NLR)with diabetic retinopathy(DR)in patient with type 2 diabetes mellitus.

METHODS:Medical records of patients with type 2 diabetes mellitus admitted to our hospital from February 2013 to July 2015 were retrospectively reviewed. Their clinical characteristics, such as MPV and NLR, were extracted. Ninety-six healthy individuals were set as a control. The relation of MPV, NLR with DR were analyzed using logistic regression model.

RESULTS:A total of 379 patients with type 2 diabetes mellitus were included in this study. Among these patients, DR was observed in 51 patients(102 eyes)with DR and 328 patients were without DR. Patients with type 2 diabetes mellitus had significantly higher MPV and NLR, compared with healthy controls. Among patients with type 2 diabetes mellitus, the patients with DR had significantly higher MPV and NLR than the patients without DR. After confounders such as disease duration and hypertension were adjusted, MPV>10fl and NLR>2.6 were independently associated with DR.

CONCLUSION:Increased MPV and NLR are independently associated with DR. Further cohort studies are needed to verify whether MPV and NLR are independent risk factors for DR.