AIM: To analyze the effect factors of trabeculectomy combined with intraoperative application of mitomycin C in the treatment of neovascular glaucoma.

METHODS: Fifty patients(50 eyes)with neovascular glaucoma collected from January 2013 to August 2015 in our hospital were treated by trabeculectomy combined with intraoperative application of mitomycin C. Single factor and multi factor variables analysis were used for effect factors of trabeculectomy combined with intraoperative application of mitomycin C in the treatment of neovascular glaucoma.

RESULTS: By results of single factor variable analysis, <50 years old, preoperative intraocular pressure(IOP)was ≥45mmHg and postoperative occurrence of anterior chamber hemorrhage were risk factors for treatment failure(P<0.05), and gender, proliferative diabetic retinopathy and previous cataract surgery and prior photocoagulation were not the risk factors for failure(P>0.05). By multivariate analysis, <50 years old and postoperative occurrence of anterior chamber hemorrhage were risk factors for treatment failure(P<0.05), and preoperative IOP≥45mmHg was not a risk factor(P>0.05).

CONCLUSION: For patients<50 years old with neovascular glaucoma, should be careful on the selection of surgical treatment. For high-risk patients, we should strengthen the monitoring and give timely intervention, which are helpful to improve the prognosis.