AIM:To investigate the differences of curative effects and security between two therapies in treating macular edema which is caused by panretinal photocoagulation: intravitreal triamcinolone acetonide and oral calcium dobesilate.

METHODS: A study was performed on the clinical material of 72 patients(72 eyes in total)with macular edema due to panretinal photocoagulation under the treatment in our hospital from Jan. 2012 to Jan. 2015. All of the 72 eyes were underwent treatment with panretinal photocoagulation because of serious diabetic retinopathy. After the treatment of panretinal photocoagulation, the patients got macular edema to varying degree, and some even acquired more serious macular edema than before. Seventy-two eyes were randomly divided into two groups, with respectively 36 eyes in each group: one was the injection group and the other was oral group. The former(patients)were treated with intravitreal injection of triamcinolone acetonide(0.025ml, 1mg); the latter(patients)took orally calcium dobesilate capsule. Best corrected visual acuity(BCVA), central macular thickness(CMT), intraocular pressure(IOP)and complications were observed before the treatment and 1mo, 3mo and 6mo after treatment.

RESULTS: There was not obvious statistical significance on basic characters between two groups(P>0.05). Intra-group comparison: after 1mo, 3mo and 6mo of treatment, BCVA and CMT in the injection group were improved significantly as compared with that before treatment(P<0.05); there were no significant differences in intraocular pressure(P>0.05). After 1mo, 3mo and 6mo of treatment, BCVA and CMT in the oral group showed no statistically significant differences before and after treatment(P>0.05); no differences were found in intraocular pressure(P>0.05). Intergroup comparison: after 1mo, 3mo and 6mo of treatment, BCVA and CMT in the injection group were improved significantly than that in the oral group(P<0.05), but there were no statistical differences in intraocular pressure between the two groups(P>0.05). After treatment, there were not any severe ocular and physical complications in two groups.

CONCLUSION: In terms of improving BCVA and CMT of patients with macular edema due to panretinal photocoagulation, the injection of 1mg intravitreal triamcinolone acetonide is more efficient than oral calcium dobesilate. Both of them are safe and didn't cause any obvious side effects or severe complications.