Abstract:AIM: To observe the efficacy and compliance of cetirizine hydrochloride and pranoprofen eye drops on children with vernal keratoconjunctivitis.
METHODS: A total of 63 children with vernal keratoconjunctivitis, from the outpatient department in our hospital between Jan. 2014 and Dec. 2015, were randomly divided into two groups including experimental group and control group. The cases in experimental group were treated with cetirizine hydrochloride, 2 times/d, 5 drops(0.25ml, 2.5mg)each time(≤6 years)or 10 drops(0.5ml, 5mg)each time(>6 years), oral or oral with beverage and food, 1g/L pranoprofen eye drops, 4 times/d, 1 drop each time. The cases in control group were only treated with cetirizine hydrochloride, 2 times /d, 5 drops(0.25ml, 2.5mg)each time(≤6 years)or 10 drops(0.5ml, 5mg)each time(>6 years), oral or oral with beverage and food for 14d. All the children were detected the scores of symptom and pathology before and after treatment. Compliance and side effect of the drug were surveyed by questionnaire.
RESULTS: The scores of symptom, pathology and overall total after treatment were significantly lower than those before treatment in each group(texperimental, symptom=10.41, P<0.05; texperimental, pathology=10.05, P<0.05; texperimental, overall=10.75, P<0.05; tcontrol, symptom=8.11, P<0.05; tcontrol, pathology=8.89, P<0.05; tcontrol, overall=8.41, P<0.05). The scores of symptom, pathology and overall total in experimental group were lower than those in control group after the treatment(tsymptom=5.27, P<0.05; tpathology=3.97, P<0.05; toverall=4.32, P<0.05). The effective rate of experimental group(85%)was significantly higher than control group(60%)(χ2=4.92, P<0.05). Most of the children(94%)had very good compliance. None of children had side effect such as sleepiness and thirst.
CONCLUSION: Cetirizine hydrochloride and pranoprofen eye drops in combination may offer a safety and effective treatment on children with vernal keratoconjunctivitis and have good compliance.
