AIM: To investigate effect of autogenous conjunctival flap transplantation in the treatment of severe fungal corneal ulcer.

METHODS: A total of 83 cases(83 eyes)with severe fungal corneal ulcer treated in our hospital from Jan.2013 to Jan.2016 were selected. Among them, 36 cases(36 eyes)were treated with drug therapy, and 47 patients(47 eyes)were treated with autogenous conjunctival flap transplantation, two group did fungal culture and identification, observed the two groups treatment effect.

RESULTS: The effective rate of surgical treatment group was 89%, significantly higher than that of drug treatment group, the difference was statistically significant(P<0.05); The effective rate of surgical treatment of filamentous bacteria was 92%, which was significantly higher than that of drug treatment, the difference was statistically significant(P<0.05). The effective rates of surgical treatment and drug treatment of yeast were 80% and 78%, the difference was not statistically significant(P<0.05).

CONCLUSION: Autologous conjunctival flap transplantation in the treatment of severe fungal corneal ulcer has good curative effect. The operation is simple, worthy of recommendation method. Filamentous bacterial corneal ulcer without good drug therapy effect, surgical treatment should be performed in a timely manner to improve the curative effect.