方法：搜集世界范围内应用吲哚青绿和亮蓝辅助内界膜剥除治疗特发性黄斑裂孔的临床对照试验的英文及中文文献。计算机检索PubMed，Ovid，ScineceDirect，NGC，EBSCO，EMBASE，CNKI，，CBM数据库。由两位系统评价员做独立文献筛查、质量评价和资料提取，并交叉核对，不同意见时经过讨论或请第三者裁决。使用统计软件Rev Man 5.3完成Meta分析。

结果：经筛选最后纳入7篇文献，均是以应用吲哚青绿对比亮蓝辅助内界膜剥除治疗特发性黄斑裂孔的临床对照试验，包括受试患者598例，通过比较术后3个主要临床指标：最佳矫正视力，裂孔闭合率和术后并发症，发现亮蓝辅助内界膜剥除组的术后6mo最佳矫正视力高于吲哚青绿组，差别有统计学意义\〖Z=2.10(P=0.04)，OR=0.10，95% CI (0.01，0.19)\〗； 在术后裂孔闭合率和并发症方面，两组比较无明显差别(P>0.05)。

结论：亮蓝辅助内界膜剥除治疗特发性黄斑裂孔术后短期内视力恢复快，优于吲哚青绿，是较理想的内界膜染色剂。建议进行大样本、长期随访的高质量临床试验，提供更佳的循证医学证据。

METHODS: All studies about indocyanine green compared with brilliant blue G for assisting internal limiting membrane peeling during macular hole surgery all over the world were searched. PubMed, Ovid, ScineceDirect, NGC, EBSCO, EMBASE, CNKI, CBM were searched. Two reviewers independently screened the studies for eligibility, evaluated the quality and extracted the data from the eligible studies, with confirmation by cross-checking. Divergence of opinion was settled by discussion or consulted by the expert. Meta-analysis was processed by Rev Man 5.3.

RESULTS: Seven trials on indocyanine green compared with brilliant blue G for assisting internal limiting membrane peeling during macular hole surgery involving 598 cases met the inclusion criteria in meta-analysis. The baseline of patients' characteristics were comparable in all studies. By comparing the three common criteria, including best corrected visual acuity(BCVA), macular hole closure rate and postoperative complications, we found that brilliant blue G was better than indocyanine green on improving best corrected visual acuity at 6mo postoperatively\〖Z=2.10(P=0.04), OR=0.10, 95% CI (0.01, 0.19)\〗. While there was no statistical difference between two groups on macular hole closure rate\〖Z=0.69(P=0.49), OR=0.95, 95% CI(0.82, 1.10)\〗. And there were no statistical differences in term of postoperative complications between two groups(P>0.05).

CONCLUSION: The available evidence indicates that the short-term recovery of best corrected visual acuity is significantly better in brilliant blue G(BBG)group than in indocyanine green(ICG)group, especially at 6mo after surgery. The long-term prognosis of BCVA which one study only reported need further study. There were no significant differences on macular hole closure rate and adverse events between two groups.The results indicate that BBG is preferable to ICG for use during macular hole surgery.