Sjögren's syndrome(SS)is a kind of chronic inflammation auto-immune disorder, which characterized by dysfunction and destruction of exocrine glands. The presentation of SS in eyes we called keratoconjunctivitis sicca(KCS). Although significant advances in both basic and clinical research have been made over the past years, the pathophysiological mechanisms of KCS are still imprecise. In vivo confocal microscopy(IVCM)is a newly emerging, noninvasive with high-resolution technology, which allows the observation of corneal cells, corneal nerves, immune and inflammatory cells, conjunctiva and meibomian gland structures on a cellular level. Therefore, it could improve the understanding of the pathogenesis and pathophysiology of the KCS. In this study, we reviewed the articles of IVCM to obtain an integrated, morphological and functional evaluation of the whole ocular surface in KCS patients with SS.