Age-related macular degeneration(AMD)is one of the main diseases in the world leading to vision loss in the elderly, and is a multi-factorial and multi-mechanism mediated chronic degenerative eye disease. The exact pathogenesis of AMD is still not clear, and many studies found that age, genetic factors, nutritional imbalance, epigenetics, oxidative stress, a variety of complement factors activation and inflammatory reaction were involved in the pathogenesis. Recent studies have found that vitamin D levels and DNA methylation were closely related to AMD. Thus, a simple generalization of vitamin D deficiency and DNA methylation in the pathogenesis of AMD were made.