AIM: To compare central corneal thickness(CCT)using Germany Allegro Oculyzer; Germany Heidelberg OCT Spectralis and Pachymetry SP-3000.

METHODS:A total of 74 cases(148 eyes)were collected in the refractive surgery center in our hospital. The cornea thickness was measured by Germany Allegro Oculyzer; Germany Heidelberg OCT Spectralis and PachymetrySP-3000 respectively. The difference of CCT was compared using t-test, the correlation and agreement was analyzed among the three methods with Pearson-test and Bland-Altman-test.

Results: Mean CCT reading of Allegro Oculyzer; Heidelberg OCT Spectralis and PachymetrySP-3000 were 532.17±22.94μm, 526.53±24.52μm and 532.62±23.59μm. The t-test showed difference between Allegro Oculyzer and Pachymetry SP-3000(P<0.05). There was significant difference between Allegro Oculyzer and Heidelberg OCT Spectralis(P<0.05). There was no significant difference between Heidelberg OCT Spectralis and PachymetrySP-3000(P>0.05). There was significant linear correlation among the three methods(r=0.972, 0.964, 0.973; P<0.05). There was good agreement among the three methods.

CONCLUSION:CCT measured by Allegro Oculyzer; Heidelberg OCT Spectralis and PachymetrySP-3000 have high correlation and agreement. The three methods are complement of each other. All can be used in measurement of CCT.