AIM: To study the ocular hypotensive effect and security of travoprost drops solution in the treatment of primary open-angle glaucoma and ocular hypertension.

METHODS: Eighty cases(eighty eyes)of patients with primary open-angle glaucoma and ocular hypertension in our hospital from Mar.2013 to Mar.2016 were randomly selected. These patients were divided into two groups according to the treatment methods, namely travoprost drops solution group(n=40)and latanoprost eye drops group(n=40), the clinical efficacy, visual acuity, astigmatism, intraocular pressure and adverse events of the two groups were analyzed.

RESULTS: The total treatment efficiency of the travoprost drops solution group 95%(38/40)was significantly higher than the latanoprost eye drops group 80%(32/40)(P<0.05). The eyesight was significantly higher(P<0.05), the astigmatism, intraocular pressure was significantly lower(P<0.05). The incidence of adverse reactions 25%(10/40)was significantly lower than the latanoprost eye drops group 53%(21/40)(P<0.05).

CONCLUSION: Travoprost drops solution in the treatment of primary open-angle glaucoma and ocular hypertension has better ocular hypotensive effect and higher safety than latanoprost eye drops.