AIM: To investigate the clinical effect and safety of intravitreal injection of Conbercept for the treatment of macular edema secondary to retinal vein obstruction.

METHODS: A total of 22 patients with macular edema secondary to retinal vein occlusion were treated in our hospital during January 2016 to Marth 2016. A total of 22 patients were given three intravitreal injections of Conbercept 0.05mL(0.5mg). Defore and after treatment, best-corrected visual acuity, fundus photography,fundus fluoreseein angiograph(FFA),optical coherence tomography(OCT)were examined.

RESULTS: A total of 22 patients were treated with intravitreal injection of Conbercept had different degrees of increase in the mean visual acuity at 1wk, 1, 2 and 3mo. The difference is statistically significant(P<0.05). OCT images show that the thickness of the central retinal thickness of the macular becomes thinner, and the difference is statistically significant(P<0.05). The FFA at 3mo showed a significant reduction in retinal leakage, obvious absorption of retinal hemorrhage.

CONCLUSION: Intravitreal injection of anti-VEGF drugs Conbercept is an effective way to treat macular edema secondary to retinal vein occlusion, it is worth to promot, but the long-term efficacy and drug injection frequency still need to study further.