方法：回顾性收集2014-06/2016-06我院行飞秒激光制瓣LASIK随访3mo的患者150例300眼，观察术前、术后1wk，1、2、 3mo患者的干眼症状评分、泪膜破裂时间(break-up time，BUT)、泪液分泌试验(Schirmer Ⅰ test，SⅠt)、角膜荧光素染色(fluorescein staining，FL)评分的变化。

结果：干眼症状评分： 术前与术后3mo比较无统计学意义(P=0.863)，术前与术后1wk，1、2mo比较有统计学意义(P=0.001、0.002、0.002)； 术后1wk与术后1mo比较无统计学意义(P=0.799)，术后1wk与术后2、 3mo比较有统计学意义(P=0.004)。BUT：术前与术后3mo比较无统计学意义(P=0.625)，术前与术后1wk、 1、2mo比较有统计学意义(P=0.029、0.017、0.002)； 术后1wk与术后1、2mo比较无统计学意义(P=0.827、0.672)，术后1mo与术后2mo比较无统计学意义(P=0.423)，术后1wk，1、2mo与术后3mo比较有统计学意义(P=0.001、0.023、0.026)。FL：术前与术后3mo比较无统计学意义(P=0.521)，术前与术后1wk，1、2mo比较有统计学意义(P=0.001、0.019、0.026)。SⅠt：术前与术后3mo比较无统计学意义(P=0.749)，术前与术后1wk， 1、2mo比较有统计学意义(P=0.000、0.002、0.006)； 术后1wk与术后1、2mo比较无统计学意义(P=0.364、0.424)，术后1wk， 1、 2mo与术后3mo比较有统计学意义(P=0.012、0.023、0.029)。多因素回归分析显示，术后视近时间、术前眼压、眼轴长度、术前BCVA及切削比为术后影响视力恢复危险因素。

结论：飞秒激光制瓣LASIK导致术后干眼的发生，但一般持续时间较短，症状较轻，在术后3mo基本能恢复至接近术前水平，其发生机制与多种因素有关； 同时，术后泪膜功能的检查结果，对术后的用药具有指导意义。

METHODS:We retrospectively analyzed 150 patients(300 eyes)selected in our hospital from June 2014 to June 2016 to and followed up for 3mo. The dry eye symptoms, break-up time(BUT), Schirmer Ⅰ test and fluorescein staining(FL)scores were observed preoperatively, 1wk, 1, 2, 3mo after operations.

RESULTS:(1)dry eye symptom score: there was no significant difference between scores before operations and 3mo after operations(P=0.863); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.001, 0.002, 0.002); there was no significant difference between scores at 1wk and 1mo after operations(P=0.799); there were significant differences between scores at 1wk after operations with 2,3mo after operations(P=0.004).(2)BUT: there was no significant difference between scores before operations and 3mo after operations(P=0.625); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.029, 0.017, 0.002); there was no significant difference between scores at 1wk and 1, 2mo after operations(P=0.827, 0.672); there was no significant differences between scores at 1 and 2mo after operations(P=0.423); there were significant differences between scores at 3mo after operations with 1wk, 1, 2mo after operations(P=0.001、0.023、0.026).(3)FL:there was no significant difference between scores before operations and 3mo after operations(P=0.521); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.001, 0.019, 0.026).(4)SⅠt: there was no significant difference between scores before operations and 3mo after operations(P=0.749); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.000, 0.002, 0.006); there were no significant differences between scores at 1wk and 1, 2mo after operations(P=0.364, 0.424); there were significant differences between scores at 3mo after operations with 1wk, 1, 2mo after operations(P=0.012, 0.023, 0.029). Multivariate analysis showed that myopia time after operations, preoperative intraocular pressure, axial length, preoperative BCVA and cutting ratio were risk factors for the recovery of visual acuity.

CONCLUSION: Dry eye occurred after femtosecond laser LASIKE, but generally last short period and symptoms were slight. Within 3mo after the operations, patients can recover the level close to the preoperative. Its mechanism is related to various factors. At the same time, the tear film function gives guidance for postoperative medication.