AIM: To study changes of tear film after femtosecond assistant laser in situ keratomileusis(LASIK).

METHODS:We retrospectively analyzed 150 patients(300 eyes)selected in our hospital from June 2014 to June 2016 to and followed up for 3mo. The dry eye symptoms, break-up time(BUT), Schirmer Ⅰ test and fluorescein staining(FL)scores were observed preoperatively, 1wk, 1, 2, 3mo after operations.

RESULTS:(1)dry eye symptom score: there was no significant difference between scores before operations and 3mo after operations(P=0.863); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.001, 0.002, 0.002); there was no significant difference between scores at 1wk and 1mo after operations(P=0.799); there were significant differences between scores at 1wk after operations with 2,3mo after operations(P=0.004).(2)BUT: there was no significant difference between scores before operations and 3mo after operations(P=0.625); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.029, 0.017, 0.002); there was no significant difference between scores at 1wk and 1, 2mo after operations(P=0.827, 0.672); there was no significant differences between scores at 1 and 2mo after operations(P=0.423); there were significant differences between scores at 3mo after operations with 1wk, 1, 2mo after operations(P=0.001、0.023、0.026).(3)FL:there was no significant difference between scores before operations and 3mo after operations(P=0.521); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.001, 0.019, 0.026).(4)SⅠt: there was no significant difference between scores before operations and 3mo after operations(P=0.749); there were significant differences between scores before operations with 1wk, 1, 2mo after operations(P=0.000, 0.002, 0.006); there were no significant differences between scores at 1wk and 1, 2mo after operations(P=0.364, 0.424); there were significant differences between scores at 3mo after operations with 1wk, 1, 2mo after operations(P=0.012, 0.023, 0.029). Multivariate analysis showed that myopia time after operations, preoperative intraocular pressure, axial length, preoperative BCVA and cutting ratio were risk factors for the recovery of visual acuity.

CONCLUSION: Dry eye occurred after femtosecond laser LASIKE, but generally last short period and symptoms were slight. Within 3mo after the operations, patients can recover the level close to the preoperative. Its mechanism is related to various factors. At the same time, the tear film function gives guidance for postoperative medication.