[关键词]
[摘要]
目的：研究2型糖尿病患者肾功能相关指标与视网膜病变发生的相关性，指导糖尿病视网膜病变早期诊断及治疗。
方法：选取2014-03/2015-12间就诊的明确诊断为2型糖尿病的295例患者。根据眼底表现情况，分为DR组和非DR组，对比分析两组患者一般资料、肾功能相关指标，基于差异性分析探讨肾功能相关指标与糖尿病患者发生视网膜病变发生相关性。
结果：与非DR组相比，DR组24h尿蛋白定量 、尿微量白蛋白/血肌酐比值、血肌酐、血尿素氮、血尿酸明显高于非DR组，差异具有统计学意义； 两组内生肌酐清除率、肾小球滤过率差异不具有统计学意义。
结论：24h尿蛋白定量、尿微量白蛋白/血肌酐比值、血肌酐、血尿素氮、血尿酸与DM患者发生DR具有相关性，而内生肌酐清除率、肾小球滤过率与DM患者发生DR无相关性。
[Key word]
[Abstract]
AIM:To guide clinical prevention for the occurrence of diabetic retinopayhy(DR)by researching the correlation between renal function and the occurrence of retinopathy in patients with type 2 diabetes mellitus.
METHODS:In this study, 295 cases were included. According to the fundus situation we divided all the cases into DR group and non-DR group. The relevant indicators of the renal function of patients in the two groups was comparatively analyzed.
RESULTS:Compared with those of non-DR group, 24h urinary protein(24h-UPr), urinary albumin / creatinine ratio(ACR), serum creatinine(Scr), blood urea nitrogen(BUN)and serum uric acid(UA)of DR group were significant higher. The creatinine clearance rate(CCR), glomerular filtration rate(eGFR)in non-DR group had no difference with those of DR group.
CONCLUSION:There has a correlation between 24h-UPr, ACR, Scr, BUN, UA and DR patients with DM, while the CCR and eGFR were not correlated with the occurrence of DR in patients with DM.
[中图分类号]
[基金项目]
北京中医药大学中青年教师面上项目课题(No.2015-JYB-JSMS071)
