AIM: To evaluate the effectiveness of vitrectomy combined with intravitreal Conbercept injection for 11 polypoidal choroidal vasculopathy(PCV)associated with vitreous hemorrhage patients.

METHODS: We retrospectively analyzed the clinical data of 11 patients(7 males and 4 females, 11 eyes)who were first diagnosed with vitreous hemorrhage between Feb. 2014 and Jul. 2015 in our hospital. These patients aged 65 to 79 years(mean 69.5±9.0y). The best corrected visual acuity(BCVA)was light perception in 1 eye, hand moving in 7 eyes, counting finger in 3 eyes. Vitrectomy combined with cataract extraction were operated in all 11 patients, which all patients were given gas tamponade. Three patients were diagnosed as polypoidal choroidal vasculopathy through fundus fluorescence angiography(FFA)and Indocyanine green angiography(ICGA)before vitrectomy(8 eyes were diagnosed as polypoidal choroidal vasculopathy after vitrectomy 1mo). Eleven patients were treated with an intravitreal Conbercept injection, received intravitreal injection of Conbercept(0.5mg, 0.05 mL)once a month for 3 consecutive months. If disease progressed or recurred during follow- up, the patients were re-injected with Conbercept. All the patients completed 12mo of follow-up after the first intravitreal Conbercept injection. The examination of the ocular fundus, B-ultrasound, best-corrected visual acuity(BCVA)and optical coherence tomography(OCT)were performed before vitrectomy, 1mo after vitrectomy and 1, 2, 3, 4, 5, 6, 9 and 12mo the first intravitreal Conbercept injection in 11 patients.

RESULTS: At 12mo of follow-up, the fundus examination revealed that the retinal deep and superficial hemorrhage of 11 patients were completely absorbed, which the subretinal orange-red lesions were still visible in 5 patients. B-ultrasound revealed that subretinal hemorrhage of 11 patients were also completely absorbed. The best corrected visual acuity of 11 patients were significantly improved, but metamorphopsia were still existence in 3 patients. The optical coherence tomography revealed that macular central retinal thickness were significantly decreased, but serous retinal pigment epithelium detachment were still existence in 6 patients.

CONCLUSION: Vitrectomy is effective for the treatment and definite diagnosis of polypoidal choroidal vasculopathy associated with vitreous hemorrhage patients. Vitrectomy combined with intravitreal Conbercept can facilitate the absorption of hemorrhage and exudates, relieve edema of the retina, promote the regression of the polyps and increase the patients' visual acuity.