AIM: To observe the clinical effect of esculin and digitalis glycosides eye drops in the treatment of teenagers' apparent fatigue caused by ametropia.

METHODS: A total of 60 cases of teenagers' patients with apparent fatigue caused by ametropia were randomly divided into 2 groups according to visual fatigue, the control group(n=30 cases)was treated with the same batch of placebo, and the observation group(n=30 cases)was treated with esculin and digitalis glycosides eye drops, two groups were treated for 6mo. The clinical efficacy of the two groups, the comfort score and refraction test results of the two groups before and after treatment, and adverse reactions were compared.

RESULTS: The total efficiency of the observation group(97%)was significantly higher than that of the control group(33%)(P<0.05). The comfort score of two groups before treatment showed no significant difference(P>0.05), the comfort score of the control group had no obvious improvement after treatment(P>0.05), and the comfort score of the observation group after treatment significantly increased more than that of before treatment and control group after treatment(P<0.05). The refractive examination results of left and right eye in two groups before treatment showed no significant difference(P>0.05), the refractive examination results of left and right eye in the control group after treatment showed no obvious improvement(P>0.05), and the refractive examination results of left and right eye in the observation group after treatment significantly improved than those of before treatment and control group after treatment(P<0.05). The adverse reaction of arrhythmia, gastrointestinal reaction, nerve neurosis incidence in the observation group(17%)had no significant difference with the control group(10%)(P>0.05).

CONCLUSION: The treatment of esculin and digitalis glycosides eye drops for teenagers' apparent fatigue caused by ametropia has a significant effect, less adverse reactions.