AIM: To investigate the clinical efficacy of combination therapy and calcium dobesilate treatment of non-proliferative diabetic retinopathy(NPDR), and staging study.

METHODS: A total of 235 patients(430 eyes)with diabetic retinopathy meeting the criteria from Jan.2014 to May 2015 were randomly divided into observation group and control group according to the admission time. One hundred and ten cases(216 eyes)in the observation group were arranged to Compound Xueshuantong Capsule(a traditional Chinese medicine)with Calcium Dobesilate therapy, 125 cases(214 eyes)in the control group were arranged with Calcium Dobesilate treatment. The visual acuity, intraocular pressure, and retinal conditions were used to assess the clinical efficacy in two groups.

RESULTS: The total effective rate was 90.3% in observation group(195 eyes / 216 eyes), which was significantly higher than control group 72.9%(156 eye / 214 eyes)(P<0.05). The significant efficiency was 22.2%(48 eyes/216 eyes)in observation group, which was significantly higher than control group 16.4%(35 eyes/214 eyes)(P<0.05).

CONCLUSION: The combination of traditional Chinese and Western medicine in the treatment of non-proliferative diabetic retinopathy clinical curative effect is remarkable.