AIM:To investigate the effect and local influence of atropine and anisodamine eye drops on adolescent pseudomyopia.

METHODS:Totally 110 cases of juvenile pseudomyopia were randomly divided into two groups, the control group was given 10g/L atropine sulfate eye gel, and the observation group was treated with 5g/L raceanisodamine eye drops. The efficacy of two methods, the changes of axial length and intraocular pressure before and after treatment, and the incidence of adverse reactions were compared.

RESULTS: There was no significant difference in cure rate between the two groups(χ²=0.533, P=0.465), but the effective rate of observation group was significantly better than the control group(χ²=3.907, P=0.048). Compared with the same group before treatment, the length of the axial length of the two groups increased in different degrees,and the increase value of the observation group was significantly higher than that of the control group, the difference was statistically significant(P<0.05), however, there was no significant difference between the two groups after treatment(P>0.05). The intraocular pressure of the two groups was significantly lower than that of the same group before treatment, and the difference between the two groups after treatments was not statistically significant(P >0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(χ²=18.939, P<0.05).

CONCLUSION: Anisodamine eye drops in the treatment of juvenile pseudomyopia has obvious curative effect, its efficacy and safety are better than atropine eye gel.