AIM:To investigate the effect of combination therapy with Ranibizumab and photodynamic therapy in the treatment of age-related macular degeneration.

METHODS: Totally 78 cases(86 eyes)with age-related macular degeneration in our hospital from January 2012 to December 2015 were selected as the subjects. The patients were randomly divided into two groups, 39 cases(42 eyes)were treated by combination as the combination group and 39 cases(44 eyes)as the control group(only treated with ranibizumab). The changes of visual acuity and choroidal neovascularization(CNV)leakage were compared between the two groups before and after treatment.

RESULTS: After treatment for 6 and 12wk, the best corrected visual acuity(BCVA)value of the combined group was higher than that of the control group, the difference was statistically significant(P<0.05); the central retinal thickness(CRT)values of the patients in the combined group were lower than those in the control group, the difference was statistically significant(P<0.05). After 12wk of treatment, the total effective rate for CNV leakage in the combined group was 90% compared with that of the control group(82%), there was no significant difference(P>0.05).

CONCLUSION: The efficacy of the combination therapy is good for CNV leakage, visual acuity and CRT in patients with age-related macular degeneration.