Abstract:AIM:To investigate the effect of dexmedetomidine hydrochloride on hemodynamics, sedation and analgesia effect during cataract surgery for senile patients with hypertension.
METHODS: Totally 90 senile patients with hypertension receiving cataract surgery were randomly divided into two groups, 45 cases in study group during the surgery by intravenous infusion of dexmedetomidine hydrochloride, 45 cases in control group were given normal saline for intravenous infusion. Blood flow dynamics index level were detected in two groups at five time points of before surgery(T0), beginning of the surgery(T1), 10 min after beginning(T2), 20 min after beginning(T3), the end of surgery(T4). Analgesia and sedation scores were compared in two groups, the incidence of adverse reactions and complications were recorded in two groups.
RESULTS: Heart rate(HR), diastolic blood pressure(DBP), systolic blood pressure(SBP)increased significantly at the time points of T1, T2, T3, T4 compared with T0 time point in the control group(P<0.05). HR, DBP, SBP decreased significantly at the time points of T1, T2, T3, T4 compared with T0 time point in the study group(P<0.05), which of the study group were significantly lower than the control group at the same time(P<0.05). Analgesia scores at the time points of T1, T2, T3, T4 were showed different degrees of decline in the two groups, and analgesia scores in the study group were significantly lower than that of the control group at the same time(P<0.05). Sedation scores at the time points of T1, T2, T3, T4 were showed different degrees of decline compared with T0 time point in the control group(P<0.05). Sedation scores at the time points of T1, T2, T3, T4 were showed different degrees of rise compared with T0 time point in the study group(P>0.05). Sedation scores in the study group were significantly higher than that of the control group at the same time(P<0.05). The incidence of adverse reactions and complications in the study group was significantly lower than that of the control group(P<0.05).
CONCLUSION: Application of dexmedetomidine hydrochloride to monitoring anesthesia during senile cataract patients with hypertension surgery, can stabilize the hemodynamics and has obvious sedation and analgesia effect.
