AIM: To investigate the clinical effect of one-dose multiple point scanning panretinal photocoagulation(PRP)in the treatment of non-proliferative diabetic retinopathy(NPDR).

METHODS:Selected 78 patients 132 eyes with NPDR in our hospital from January 2015 to June 2016, the patients were randomly divided into observation group(42 patients of 72 eyes)and control group(36 patients of 60 eyes). The observation group was given one-dose multi-point scanning PRP. The control group was given a single point scanning, 3 to 4 times to complete the PRP. To observethe therapeutic effect in two groups, the average visual field threshold, the flash electroretinogram(F-ERG)a, b wave amplitude, the laser energy and so on were observed.

RESULTS:The effective rate of the observation group and the control group were 84.7% and 83.3%, the difference was not statistically significant(P>0.05). In the observation group and the control group, at 6mo after treatment, the leakage area of retinal neovascularization was lower than that before treatment(P<0.05). The visual field threshold and F-ERG a wave amplitude differences were not statistically significant(P>0.05). F-ERG b wave amplitude were 221.94±70.18mV and 219.82±69.56mV in the observation group and the control group at 6mo after treatment which were significantly lower than that before treatment(P<0.05). The laser energy of the observation group was 541.23 ± 56.39mW, significantly higher than the control group 326.39±78.83mW(P<0.05), while the energy density was 0.34±0.14mW·ms/mm², significantly less than the control group 2.01±0.97mW·ms/mm²(P<0.05). The incidence of complications in the observation group and the control group were 8.3% and 15.0%, the difference was statistically significant(P<0.05).

CONCLUSION:The clinical effect of multiple point scanning PRP in the treatment of NPDR is better than single point multiple PRP with advantages of lower energy density and less laser damage.