AIM: To investigate the clinical effect of panretinal photocoagulation(PRP)combined with calcium dobesilate in treatment of diabetic retinopathy(DR).

METHODS: Selected 120 cases(240 eyes)of DR diagnosed in our hospital from January 2011 to January 2016 were retrospectively analyzed. According to whether calcium dobesilate was used, the treatment group was divided into two groups. Sixty cases were treated with PRP combined with calcium dobesilate, and 60 cases in the control group were treated with PRP only. The BCVA, CMT and clinical efficacy of the two groups were compared.

RESULTS: Before treatment, there was no significant difference on BCVA between combined group and control group(P>0.05). After treatment, BCVA of combined group was higher than that of the control group(P<0.01). Before the treatment, no statistically significant difference between combined group and control group on CMT, neovascularization and fluorescein leakage area were found(P>0.05); after treatment, the combination group on CMT, neovascularization and fluorescein leakage area value were less than the control group(P<0.01). After treatment, combined group was appearance effect in 65.0%, effective in 30.0%, invalid in 5.0%, the control group was 50.8%, effective 36.7%, invalid 12.5%, all statistically significant differences between the two groups(P<0.05).

CONCLUSION:PRP combined with calcium dobesilate in treatment of DR has a more significant clinical effect than PRP alone.