AIM: To explore the application effect of pranoprofen combined with tobramycin and dexamethasone ophthalmic suspension in cataract extraction after IOL implantation.

METHODS: Retrospective analysis of the clinical data of cataract patients treated from May 2015 to June 2016 in our hospital. According to the treatment methods, patients were divided into tobramycin and dexamethasone ophthalmic suspension with pranoprofen group(combined treatment group)and pranoprofen treatment group. The difference of visual acuity, intraocular pressure, anterior chamber flash change, satisfaction rate and symptom score before and after treatment in two groups were observed.

RESULTS: The vision of the two groups before treatment had no difference(P>0.05). At 1wk and 1mo after treatment, the visual acuity of the two groups all improved compared with before treatment, there was no significant difference between the two groups(P>0.05). Before treatment, the anterior chamber flare of the two groups had no difference(P>0.05). At 1wk and 1mo after treatment, the anterior chamber flare of combined treatment group was lower, the difference was statistically different(t=2.435, 1.864; P<0.05). The symptom score of the two groups before treatment had no difference(P>0.05). After treatment, the symptoms and signs of combined treatment group was significantly lower than that of pranoprofen group(t=2.586, 7.820; P<0.05). The satisfaction rate of the combined treatment group patients was 100%, significantly higher than pranoprofen group.

CONCLUSION: Pranoprofen and tobradex in the treatment of cataract extraction and intraocular lens implantation has good application effect, can significantly improve the patient's symptoms and signs.