AIM: To study the clinical effect of silica gel drainage tube combined with lomefloxacin hydrochloride eye ophthalmic gel in the treatment of lacrimal duct obstruction.

METHODS: Totally 86 cases(138 eyes)of lacrimal duct embolism treated in our hospital from February to December 2015 were divided into 43 cases(68 eyes)as control group and 43 cases(70 eyes)of the observation group according to whether they were treated with lomefloxacin hydrochloride eye ophthalmic gel. Patients in the control group were treated with silica gel drainage, while the observation group was treated with lomefloxacin hydrochloride eye ophthalmic gel on the basis of the control group. The total effective rate, serum hypersensitivity C-reactive protein(h-CRP)level, complications and recurrence rate were observed and compared between the two groups.

RESULTS: The total effective rate in the patients with obstructive nasolacrimal duct, common lacrimal duct obstruction, and lacrimal duct obstruction in observation group were 95.2%, 100.0%, 96.7%, higher than those in control group(P<0.05). There was no significant difference between the two groups in preoperative serum h-CRP levels(P>0.05). The serum levels of h-CRP in patients in the observation group at 3d and 7d after operation respectively were 2.40±0.84g/mL, 1.94±0.84g/mL, lower than those of control group at the same time(P<0.05). The complication rate of the observation group was 1.4%, which was lower than that of the control group(P<0.05). Follow up for 6-18mo, the recurrence rate was 11.4% in the observation group, which was significantly lower than the control group(P<0.05).

CONCLUSION: The combination of silica gel drainage tube and lomefloxacin hydrochloride eye ophthalmic gel in the treatment of obstruction of lacrimal duct has good clinical efficacy, low inflammatory reaction, low complication rate and low recurrence rate.