AIM: To evaluate the effects and safety of intravitreal injection of triamcinolone acetonide(TA)or conbercept combined with macular laser grid photocoagulation in the treatment of macular edema secondary to retinal vein occlusion(RVO).

METHODS: Fifty cases(50 eyes)with macular edema secondary to retinal vein occlusion were selected and assigned to 2 groups: intravitreal injection of TA or conbercept, and laser photocoagulation after 7d. Best corrected visual acuity(BCVA), fundus examination, optical coherence tomography(OCT)and intraocular pressure(IOP)were examined before intravitreous injection and 14d, 1 and 3mo after laser, fundus fluorescein angiography(FFA)were examined 3mo after treatment. The postoperative results at each time point were compared with preoperative values.

RESULTS: Two kinds of treatment compared with preoperative, the BCVA all increased in various degrees. At 14d after intravitreous injection, 1 and 3mo after laser, the ratio of vision improved in TA group was 76%, 80%,68%, conbercept group was 88%, 92%, 88%, BCVA of two groups in each period all had varying degrees of increase than preoperative. The best BCVA acquired at 1mo after treatment. The macular thickness after treatment was significantly lower than preoperative in two groups. At preoperative, 14d, 1 and 3mo after treatment, the macular thickness in TA group was 557.5±150.9, 301.7±120.1, 262.7±131.2, 338.1±146.5μm; the macular thickness in conbercept group was 569.4±135.9, 282.3±133.5, 259.5±116.4, 307.8±122.6μm. The macular thickness of the two groups were significantly different between preoperative and postoperative.

CONCLUSION: The combination of intravitreous injection of TA or conbercept with macular laser grid photocoagulation can be an effective method in the treatment of macular edema secondary to RVO, conbercept treatment is more effective and security.