白藜芦醇在年龄相关性眼病中的研究进展
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国家自然科学基金资助项目(No.81271425)


Research progress on the role of resveratrol in age-related eye diseases
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National Natural Science Foundation of China(No. 81271425)

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    摘要:

    年龄相关性眼病是指随着年龄增长,由眼退行性改变引起的一系列眼科疾病,青光眼、白内障和年龄相关性黄斑变性(age-related macular degeneration,AMD)是常见的几种年龄相关性眼病,炎症反应和氧化应激在其发病过程中扮演着重要角色。白藜芦醇是一种天然植物抗毒素,通过调节多个细胞转导通路发挥抗氧化应激、抗炎作用,已成为抗衰老领域的研究热点,并取得了较大进展。目前,白藜芦醇与年龄相关性眼病的研究仍处于初始阶段,本文重点介绍白藜芦醇在年龄相关性眼病中的最新研究进展。

    Abstract:

    Age-related eye diseases are a set of ophthalmic diseases caused by aging and irreversible degeneration in the eye. Glaucoma, cataract, and age-related macular degeneration(AMD)are some of the common age-related eye diseases. Inflammation and oxidative stress play important roles in the initiation and progression of these diseases. Resveratrol, a natural plant antitoxin, fights oxidative stress and inflammation by regulating multiple cellular transduction pathways; and it has become a focal point in anti-aging research and has seen significant research progress during recent years. At the present, investigation into the relationship between resveratrol and age-related eye diseases is still in its infancy. This paper focuses on elaborating new research progress on resveratrol's role in age-related eye diseases.

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李晔,李丽萍,赖玉清,等.白藜芦醇在年龄相关性眼病中的研究进展.国际眼科杂志, 2017,17(11):2050-2054.

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  • 收稿日期:2017-06-15
  • 最后修改日期:2017-09-22
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  • 在线发布日期: 2017-10-19
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