AIM:To observe the clinical efficacy after LASIK with corneal flap created by femtosecond laser and microkeratome.

METHODS: The ophthalmic myopia patients after LASIK with corneal flap created by femtosecond laser or microkeratome in our hospital, 50 cases(100 eyes)each, were inspected for uncorrected vision, residual diopter, dry eyes survey, higher order aberrations at 1, 3 and 6mo after surgeries.

RESULTS: There were no statistical differences between two groups of uncorrected vision and residual diopter in 6mo after surgery(P>0.05). The incidence of dry eye comparison for postoperative 1 and 3mo were significantly different(P<0.05), but there were no statistical differences for postoperative 6mo(P>0.05). The higher order aberrations of the two groups increased after surgery, the differences were significant compared with preoperative(P<0.05). At 1mo after surgeries, horizontal coma aberration, vertical coma aberration and spherical aberration were not significantly different(P>0.05). At 3 and 6mo after surgeries, horizontal coma aberration and vertical coma aberration were not significantly different(P>0.05).

And the change of spherical aberration after LASIK with corneal flap created by femtosecond laser was less than that with microkeratome(P<0.05).

CONCLUSION:LASIK with corneal flap created by femtosecond laser is a safe, effective and stable surgical approach. The incidence of dry eye is low; the postoperative visual quality is better than LASIK with corneal flap created by microkeratome.