AIM: To observe the efficacy and safety of intravitreal injection of anti-vascular endothelial growth factor(VEGF)combined with laser photocoagulation in treatment of diabetic macular edema.

METHODS: Retrospective analysis on clinical data of 86 patients(102 eyes)with diabetic macular edema and they were divided into 2 groups randomly. The control group adopted laser photocoagulation treatment; observation group accepted anti-VEGF treated basis on control group(Conbercept 0.05mL). We compared the effects and the adverse reactions of the two groups.

RESULTS: After treatment, visual acuity of the two both increased; the observation group's situation was better than the control group(P<0.05). After treatment, the total efficiency rate of the observation group was 90.9%, which was higher than that of the control group of(76.6%, P<0.05). After treatment, the macular retinal thickness(CRT)and total macular volume(TMV)levels of the two group decreased, and the CRT and TMV of observation group were lower than the control group(P<0.05); there was no significant difference between the two groups on adverse reactions(P>0.05).

CONCLUSION: The efficacy on diabetic macular edema by intravitreal injection of anti VEGF drug combined with laser photocoagulation is better, can reduce the CRT, TMV in the range of 6mm, and application security is good.