AIM:To investigate the clinical effect of compound Xueshuantong capsule combined with calcium dobesilate in the treatment for patients with early diabetic retinopathy(DR).

METHODS: According to the random table method, 54 cases of DR patients(68 eyes)in the ophthalmological clinic of our hospital from February 2015 to November 2016 were divided into control group and research group with 27 cases(34 eyes)in each group. Patients in the control group were treated with calcium dobesilate tablets, while patients in the research group were treated with compound xueshuantong capsule based on the control group. The duration of treatment was 5mo in both groups. The total clinical efficiency of the two groups was calculated, and the visual, blood glucose and inflammatory factors of the two groups were detected before and after treatment, in addition the adverse reaction and recurrence rate were observed.

RESULTS: The total clinical efficiency of the patients in the research group was 91%(31/34), which was significantly higher than 68%(23/34)of the control group(P<0.05). Compared with before treatment, the vision, the volume of hemangioma, macular thickness, plaque area, grey value view, blood glucose and inflammatory factor levels of two groups of patients after treatment dropped significantly, meanwhile the vision, blood sugar and inflammation index levels of research group were better than control group, and the differences were statistically significant(P<0.05). No adverse reactions occurred during the treatment of the two groups. The recurrence rate of research group was 3%(1/31), which was significantly lower than that of the control group as 26%(6/23)(P=0.039).

CONCLUSION: The curative effect of compound xueshuantong capsule combined with calcium dobesilate in the treatment of patients with early DR is significant. It can significantly improve eyesight, blood glucose and inflammatory response and has a good forward curative effect.