AIM: To explore relation of diabetes mellitus with intraoperative floppy-iris syndrome(IFIS)during phacoemulsification.

METHODS: Thirty patients with IFIS who underwent phacoemulsification were enrolled as IFIS group. The patients in whom IFIS did not appear were as the control group. The baseline data of two groups were collected. The risk factors of IFIS in phacoemulsification were analyzed by Logistic regression analysis. The forecasting indicators of IFIS were analyzed by ROC curve.

RESULTS: Logistic regression analysis showed that diabetes(Exp(B)=1.514, 95% CI: 0.842-5.281\〗, fast plasma glucose(FPG)\〖Exp(B)=1.958, 95% CI: 1.163-11.728\〗, HbA1c \〖Exp(B)=2.044, 95% CI: 1.409-14.620\〗 and the history of application of α-1 receptor antagonists \〖Exp(B)=1.791,95% CI: 1.128-10.752\〗 were independent risk factors for IFIS in cataract phacoemulsification. The AUC of FPG predicting IFIS was 0.645. And The AUC of HbA1c predicting IFIS was 0.767. The sensitivity of FPG ≥7.0mmol/L predicting IFIS was 0.849, the specificity was 0.241. The sensitivity HbA1c> 9.0% predicticting IFIS, was 0.733, specificity was 0.600.

CONCLUSION: The occurrence of IFIS in phacoemulsification is related to the history of of diabetes, FPG, HbA1c and application of α-1 receptor antagonist. The preoperative measure HbA1c has a good predictive value of IFIS.