Abstract:AIM: To investigate the clinical characteristics of patients with systemic lupus erythematosus(SLE)complicated with retinopathy.
METHODS: Totally 121 cases of SLE patients treated in our hospital from February 2015 to February 2017 were selected, including 30 cases with retinopathy(observation group)and 91 cases without retinopathy(control group), the clinical manifestations and laboratory examination results of the two groups were compared.
RESULTS: In the observation group, there were 6 patients with bilateral retinopathy and 24 patients with monocular retinopathy. Cotton retinal exudation, retinal vascular occlusion and retinal hemorrhage lesions were common, accounted for 33%, 25% and 19%. The incidence of skin rash, skin vasculitis and Raynaud's phenomenon in the observation group were 63%, 47% and 37%, respectively, which were significantly higher than those in the control group(P<0.05). There were no significant difference in the incidence of mucosal ulcer, arthritis, neuropsychiatric symptoms and pleurisy between the observation group and the control group(P>0.05). The positive rate of anti ds-DNA in the observation group was 63%, which was significantly higher than that in the control group(P<0.05). The observation group and the control group urine protein ≥3+, anti Sm antibody positive and rRNP positive and antiphospholipid antibody percentage differences were not statistically significant(P>0.05). The SLEDAI score of the observation group was 20.14(9, 30)points, which was significantly higher than that of the control group(P<0.05). The modified BenEzra score of the observation group was 10.04±3.15, and was positively correlated with the SLEDAI score(rs=0.706, P<0.05).
CONCLUSION: SLE with fundus retinopathy patients mainly manifest as cotton wool spots, retinal vascular occlusion and retinal hemorrhage; rashes, vasculitis, Raynaud's phenomenon, and anti ds-DNA antibodies are common in SLE patients with retinopathy. The modified BenEzra score plays an important role in the evaluation of SLE disease activity and retinal vascular lesions.
