Abstract:AIM: To evaluate the traditional Chinese medicine(TCM)for the treatment of dry eye effect in the past five years by using meta analysis method.
METHODS: According to the Cochrane evaluation system method, we searched Medline(January 2013 to October 2017), EMbase(2013-2017), Cochrane Library(2017), Wanfang database(2013-2017), VIP(2013-2017), and CNKI(2013-2017)for studies published. We included randomized controlled trials conducted the TCM in the treatment of dry eye. RevMan 5.0 statistical software data extraction and Meta analysis were conducted.
RESULTS: A total of 10 studies were identified, nine were from Chinese literature and one was from English literature, of which including 1 229 eyes. Nine of these studies performed BUT measurements at the end of the course of treatment. The results showed a statistically significant difference(P<0.00001). Nine studies performed tear flow measurements at the end of the course of treatment and the results showed a statistically significant difference(P<0.0001). Two studies performed FL measurements after the end of the course of treatment; the results showed no statistically significant difference(P=0.25). Three studies performed dry eye symptoms after the end of the course of treatment; the results showed that the differences were statistically significant(P=0.0003); the overall efficacy comparison, the difference between the two groups was statistically significant(P<0.00001).
CONCLUSION: TCM treatment can significantly prolong BUT and increase tear flow, and has more advantages in the treatment of dry eye.
