AIM: To explore the effect of intravitreal injection of Conbercept combined with 23G minimally invasive vitrectomy on retinal hemorrhage, retinal proliferation and visual prognosis in patients with proliferative diabetic retinopathy(PDR).

METHODS: Totally 56 cases of PDR patients(56 eyes)admitted to our hospital were randomly divided into the conbercept group(n=28)and the pars plana vitrectomy(PPV)group(n=28). The conbercept group was given intravitreal injection of Conbercept and 23G minimally invasive vitrectomy, and the PPV group was given the 23G minimally invasive vitrectomy only. The operative time, retinal hemorrhage, retinal proliferation and visual acuity were compared between the two groups.

RESULTS: The operative time and intraoperative blood loss in the conbercept group were significantly lower than those in the PPV group(P<0.05). The visual acuity and macula thickness in the conbercept group were significantly better than those in the PPV group(P<0.05). The postoperative retinal hemorrhage score, retinal proliferative score, vitreous rebleeding rate and vascular endothelial growth factor(VEGF)level in the conbercept group were significantly lower than those in the PPV group(P<0.05).

CONCLUSION: Intravitreal injection conbercept combined with 23G minimally invasive vitrectomy for PDR can not only shorten the operative time, reduce the intraoperative retinal hemorrhage and postoperative rebleeding and the retinal proliferation, but also help patients with postoperative visual acuity recovery.