AIM: To investigate the effect of calcium dobesilate on vitreous hemorrhage in patients with proliferative diabetic retinopathy(PDR)after pan retinal photocoagulation(PRP).

METHODS:Totally 62 patients(30 cases with binocular lesions, 32 cases with monocular lesions, a total of 92 eyes)with PDR who were treated in our hospital from January 2015 to July 2017 were selected as the subjects. They were divided into the control group(treated with pan retinal photocoagulation, n=30, 17 cases with monocular lesions, 13 cases with binocular lesions, a total of 43 eyes)and the study group(treated with calcium dobesilate on the basis of treatment for the control group, n=32, 15 cases with monocular lesions, 17 cases with binocular lesions, a total of 49 eyes). The recovery of visual acuity, blood rheology(plasma viscosity, hematocrit, erythrocyte deformation index)and the incidence of complications such as vitreous hemorrhage in the two groups after surgery were observed.

RESULTS: There was no significant difference between the two groups in the rate of excellent and good visual acuity, plasma viscosity, hematocrit or erythrocyte deformability index before treatment(P>0.05). After treatment, the rate of excellent and good visual acuity in the study group was significantly higher than that in the control group(P<0.05). After treatment, the plasma viscosity and hematocrit decreased significantly while the erythrocyte deformability index significantly increased only in the study group, and changes of above-mentioned indexes in the study group were more obvious than those in the control group after treatment(P<0.05). The incidence rate of vitreous hemorrhage and total incidence rate of complications in the study group were significantly lower than those in the control group(P<0.05).

CONCLUSION: The application of calcium dobesilate in patients with PDR after pan retinal photocoagulation can effectively improve the recovery of visual acuity and reduce the incidence of complications such as vitreous hemorrhage. The mechanism may be related to effectively improving the hemodynamics.