AIM:To discuss the clinical efficacy of 27-gauge(27G)vitrectomy with proliferative membrane cutting in situ for late proliferative diabetic retinopathy(PDR).

METHODS: Collecting 10 cases(15 eyes)with late PDR from January 2017 to August 2017 which underwent 27G microincision vitrectomy with cutting proliferative membrane in situ, we observed the rate of intraoperative iatrogenic retinal hole(IRH), the rate of silicone oil tamponade, the best corrected visual acuity(BCVA)and intraocular pressure(IOP)before and after operation.

RESULTS: IRH occurred in 4 eyes(27%, 4/15); Silicone oil was tamponaded in 6 eyes(40%, 6/15); BCVA was improved in 13 eyes and only 2 eyes unchanged 3mo after operation. The best visual acuity(VA)was 0.6. There was significant difference on BCVA between preoperative and postoperative 7d(P<0.05). The same was found between preoperative and postoperative 1mo, even 3mo(P<0.05). The average preoperative IOP was 16.95±6.87mmHg and postoperative 3mo was 15.27±4.57mmHg. There was no significant difference between them(P>0.05).

CONCLUSION: The 27G vitrectomy with cutting proliferative membrane in situ method is markedly superior in the treatment of late PDR, and the curative effect is specific. It can be given preference to late PDR.