AIM:To evaluate the effectiveness of visian implantable collamer lens with central hole(ICL V4c)implantation for the correction of high myopia using the double-pass visual quality analysis system.

METHODS: Totally 60 eyes of 30 high myopia patients who underwent ICL V4c implantation were enrolled into this prospective randomized control study. Myopic degree of selected patients was -6.0D to -12.0D, age 18 to 35 years old, best corrected visual acuity(BCVA)≥0.6, preoperative corneal astigmatism acuities ≤1.0D. All patients were taken the temporal side transparent corneal incision. The patients were evaluated postoperatively 1wk, 1 and 3mo respectively. The evaluating items included preoperative BCVA, postoperative uncorrected visual acuity(UCVA), objective scattering index(OSI), and modulation transfer function(MTF)cut off frequency, Strehl ratio(SR), and 100%, 20%, 9% Optical Quality Analysis System(OQAS)Value(OV, contrast visual acuity). All statistical analyses were performed with SPSS19.0 statistical software. Variance analysis of repeated measurement data was employed.

RESULTS: The UCVA gradually improved at 1wk, 1 and 3mo after surgery. There was statistical significance compared with the preoperative BCVA(P<0.01). The postoperative OSI, MTF cut off, SR, OV 100%, OV 20% and OV 9% at 1wk, 1 and 3mo showed statistically differences compared with the preoperative values(P<0.05).

CONCLUSION: ICL V4c implantation can effectively correct high myopia range from -6.0D to -12.0D. The postoperative OSI were smaller than the preoperative OSI. The postoperative UCVA were better than the preoperative BCVA. The value of postoperative MTF cut off, SR, and OV value of 100%, 20% and 9% improved.