目的：研究通滞活络颗粒冲剂联合复方樟柳碱对中老年后天性眼肌麻痹的临床治疗效果。

方法：选择2015-01/2017-10在我院进行诊治的81例81眼中老年后天性眼肌麻痹患者，按治疗方式的不同分为观察组40例40眼和对照组41例41眼。对照组在患侧颞浅动脉旁给予皮下注射复方樟柳碱2mL，观察组在对照组的治疗基础上联合服用通滞活络颗粒冲剂。比较两组的临床治疗效果、复视像距离及治疗前后基底动脉收缩期的搏动指数以及血流速度。

结果：观察组中老年后天性眼肌麻痹患者的有效率为92%(37/40)，明显高于对照组的73%(30/41，P<0.05)； 观察组治愈时间≤2wk的发生率明显高于对照组(P<0.05)； 两组治疗后的复视像距离均明显缩短(P<0.01)，且观察组复视像距离明显短于对照组(P<0.01)； 两组治疗后的搏动指数均明显降低(P<0.01)，血流速度均明显升高(P<0.01)，且观察组更为明显(P<0.01)。

结论：通滞活络颗粒冲剂联合复方樟柳碱对中老年后天性眼肌麻痹的临床治疗效果明显优于单纯皮下注射复方樟柳碱，可有效改善椎-基底动脉的血流状况，具有较高的临床应用价值。

METHODS:We selected 81 patients(81 eyes)with acquired ophthalmoplegia in the middle-aged and elderly who were diagnosed and treated in our hospital from January 2015 to October 2017. All patients were divided into observation group(n=40)and control group(n=41)by treatment methods. The control group was given subcutaneous injection of compound anisodine 2mL near the superficial temporal artery of the affected side. The observation group was combined with Tongzhihuoluo Granules. The clinical efficacy and diplopia distance were compared between the two groups. The pulsatility index and blood flow velocity of the basilar artery before and after treatment were compared between the two groups.

RESULTS: The effective rate of ophthalmoplegia in the observation group was 92%(37/40), which was significantly higher than that in the control group(73%, 30/41; P<0.05). The incidence of cure time ≤ 2wk in the observation group was significantly higher than that in the control group(P<0.05). The recombination distances after treatment in both groups were significantly shortened(P<0.01), and the diplopia distance in the observation group was significantly shorter than that in the control group(P<0.01). The pulsation index of both groups were significantly lower after treatment(P<0.01), and the blood flow velocity was significantly increased(P<0.01), and those of the observation group changed more(P<0.01).

CONCLUSION: The clinical therapeutic effect of Tongzhihuoluo Granules combined with compound anisodine on the acquired ophthalmoplegia in middle-aged and elderly patients is significantly better than that of compound anisodine, which can effectively improve the blood flow of vertebral-basal artery and has high clinical efficacy.