AIM: To explore the clinical effect of small incision lenticule extraction(SMILE)and femtosecond laser in situ keratomileusis(FS-LASIK)in correcting high myopia and the effect on cornea and tear film stability.

METHODS: Totally 120 patients with high myopia treated in the hospital from August 2016 to February 2017 were selected as the research subjects. According to the surgical methods, the patients were divided into SMILE group and FS-LASIK group, 67 cases 134 eyes in SMILE group and, and 53 cases 106 eyes in FS-LASIK group. Group SMILE was treated with SMILE, and group FS-LASIK was treated by FS-LASIK. The influence of normal vision and stability of cornea and tear film.

RESULTS: There was no significant difference in uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA)and diopter between two groups after 1mo and 3mo(P>0.05). There was no significant difference in BUT and SⅠt between the two groups of patients before and 1mo after operation(P>0.05). After 3mo between the two groups, BUT and SⅠt in the two groups were statistically different, and the SMILE group was significantly better than the FS-LASIK group(P<0.001). There was no significant difference between the two groups of corneal thinning point height and posterior vertex height at preoperative and postoperative 1 and 3mo(P>0.05).

CONCLUSION: SMILE and FS-LASIK are equally safe and effective and have good predictability and stability. The postoperative tear film stability is superior to FS-LASIK, and there is no significant difference in the biomechanical stability of the two kinds of methods.