局部抗青光眼药物的回顾性研究
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佛山市卫生和计生局医学科研课题(No.20180104)


Retrospective study of topical medical treatment for glaucoma
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Medical Research Project of Foshan Health and Family Planning Bureau(No. 20180104)

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    摘要:

    目的:通过回顾性分析佛山市第二人民医院(地方三甲医院)2009/2016年门诊处方中局部降眼压药物,分析过去8a该院青光眼药物使用频度和变化趋势。

    方法:回顾性分析2009-01-01/2016-12-31于我院门诊就诊的所有青光眼患者局部抗青光眼药物使用情况。分年度比较各类药物处方频次百分比,单药与联合用药的构成比及用药频度。

    结果:β-肾上腺素能受体阻滞剂的处方频次构成比由2009年的81.51%下降为2016年的69.37%; 拟胆碱能类药物由2009年的12.04%下降为2016年的3.78%; 前列腺素类衍生物由2009年的8.40%上升为2016年的31.40%; α2-肾上腺素能受体激动剂由2009年的0上升为2016年的29.44%; 局部碳酸酐酶抑制剂变化不大。单用一种药物的比例由2009年的65.83%,降为2016年的46.22%,两种药物联合使用的比例由2009年的32.49%增加为2016年的38.77%; 三种药物联合使用的比例在2009年时为1.68%,到2016年时为12.96%; 四种药物联合使用的比例在2009年时为0,到2016年时增为1.97%; 而五种药物联合使用属个别情况。

    结论:局部青光眼药物使用频度发生了显著的变化。β-肾上腺素能受体阻滞剂和拟胆碱能类药物的使用频度逐年下降,前列腺素类衍生物和α2-肾上腺素能受体激动剂的使用频度逐年上升。单用一种药物的比例在逐年降低,联合用药的比例则在逐年增加。

    Abstract:

    AIM:To document the change in pattern of topical anti-glaucoma medicine by retrospective analysis in the outpatient of a local tertiary eye hospital(Second People's Hospital of Foshan)in China during 2009-2016.

    METHODS: The data of topical anti-glaucoma medications in outpatients in our hospital were collected from January 1st 2009 to December 31st 2016. These data were analyzed retrospectively. The main outcome measures were the percentages of prescriptions for all kinds of anti-glaucoma medications, the ratio of the mono-therapy and combination therapies, and the defined daily doses.

    RESULTS: The ratio of beta-adrenergic receptor blocker declined from 81.51% in 2009 to 69.37% in 2016. The use of cholinergic agent decreased from 12.04% in 2009 to 3.78% in 2016. The prostaglandin derivatives increased from 8.40% in 2009 to 31.40% in 2016. Alpha 2 adrenergic receptor agonists increased from 0 in 2009 to 29.44% in 2016. Local carbonic anhydrase inhibitors changed slightly. The proportion of mono-therapy was reduced from 65.83% in 2009 to 46.22% in 2016. The ration of two agents combination increased from 32.49% in 2009 to 38.77% in 2016. The three medications combination was increased from 1.68% in 2009 to 12.96% in 2016. The proportion of four medications combination increased from 0 in 2009 to 1.97% in 2016, while the combined use of five drugs was an isolated case.

    CONCLUSION: The proportion of topical anti-glaucoma agents has changed remarkably. The beta-adrenergic receptor blockers and cholinergic medications are decreasing, while the prostaglandin derivatives and alpha 2 adrenergic receptor agonists are increasing. The proportion of mono-therapy is declining, while the combined therapies are rising.

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郭秀娟,陈菂,吴海霞,等.局部抗青光眼药物的回顾性研究.国际眼科杂志, 2018,18(10):1893-1897.

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  • 收稿日期:2018-05-04
  • 最后修改日期:2018-09-04
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  • 在线发布日期: 2018-09-14
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