AIM:To evaluate the clinical efficacy of treatment via disinhibition and visual function training in children patients with anisometropic amblyopia.

METHODS: Eighty-three children patients with anisometropic amblyopia were enrolled in the prospective case control study. All patients were monocular amblyopia, which were randomly classified into 2 groups as a training group(44 cases)and a control group(39 cases). All patients had routine glasses and quantitative coverage, and were treated by the combination of both family and clinic training. Patients in both control and training groups were treated by amblyopia training instrument(light brush, red flash, grating, etc.)and fine stimulation training via computer software. Additionally, patients in the training group, whose corrected vision improved more than 0.6, were also exposed to other treatments including monocular adjustment function training, disinhibition training, binocular adjustment function training, binocular integration and fusion function training. Visual acuity and outcomes were statistically analyzed after 6mo.

RESULTS: No significant difference in the total effective rate of vision improvement between the two groups. However, the overall visual acuity difference between the two groups was statistically significant(P<0.05). After disinhibition and visual function training, the number of patients with improvement in both far and near stereopsis in the training group was significantly greater than that in the control group(P<0.05).

CONCLUSION: Combinational treatment with disinhibition and binocular visual function training enhances the competitiveness of amblyopic eyes and eliminate inhibition, which is accompanied by improved visual acuity and ameliorated visual function in children patients with anisometropic amblyopia.