AIM:To explore the photodynamic therapy(PDT)combined with intravitreal injection of Ranibizumab(IVR)on visual acuity, central macular thickness(CMT)and postoperative complications in the treatment of polypoidal choroidal vasculopathy(PCV)complicated with vitreous hemorrhage(VH).

METHODS: Totally 71 cases of patients(71 eyes)with PCV complicated with VH were divided into two groups according to the treatment methods. And observation group(n=43)was given PDT with IVR after vitrectomy, and control group(n=28)was only given IVR adjuvant treatment. The best corrected visual acuity(BCVA), CMT and postoperative complications were followed up at the 1^st, 3^rd and 6^th month after treatment.

RESULTS: After treatment, the BCVA in the two groups was gradually improved while the CMT was gradually decreased with time, and the difference within-groups at different times was statistically significant(P<0.05), and there were statistically significant differences in BCVA and CMT between the two groups at the same time after treatment(P<0.05). After treatment, the closure of CNV lesion in observation group was significantly better than that in control group(P<0.05), and the complete closure rate was higher than that in control group(χ²=4.508, P<0.05). There was 6 cases(14%)of related complications in observation group after treatment and 5 cases(18%)in control group, and there was no statistically significant difference between the two groups(P>0.05).

CONCLUSION: PDT combined with IVR for patients with PCV and VH after vitrectomy is beneficial to promote the absorption of vascular exudate and the elimination of polypoid lesions, thus reducing macular edema, improving the visual acuity and reducing postoperative complications. And its clinical efficacy and safety are worthy of recognition.