AIM: To investigate the clinical efficacy of visual function training in the late stage of ametropic amblyopia treatment.

METHODS: One hundred and twenty two children patients and 244 eyes with ametropic amblyopia, which were ranged from January 2016 to December 2016, were enrolled in the prospective case control study. Patient inclusion criteria: spherical power≤ ±3.00D, absolute value of astigmatism(hereinafter referred to as the degree of astigmatism)≥2.00D, binocular spherical lens difference ≤1.50D, binocular cylinder difference ≤1.00D. All patients received preliminary treatment. After routine optometry and amblyopia treatment, visual acuity in amblyopic eyes improved to more than 0.6 and visual acuity difference between two eyes should be less than 2 lines in visual chart testing. Enrolled patients were randomly assigned into a training group(62 cases 124 eyes)and a control group(60 cases 120 eyes). All patients had routine glasses with a combination of both family and clinic training. Treatments in the control group included: amblyopia training instrument(light brush, red flash and grating etc.)and fine stimulation training through computer software. In addition to similar treatments in control group, patients in training group also received following treatments including monocular adjustment function training, binocular adjustment function training, binocular integration and fusion function training. After 6mo, visual acuity, near stereopsis, adjustment amplitude, adjustment sensitivity and adjustment response tests were compared and statistically analyzed in patients of both control and training groups.

RESULTS: Our data demonstrated that the overall visual acuity was significantly improved in training group(P<0.05). Additionally, results of near stereopsis function, adjustment amplitude, adjustment sensitivity and adjustment response examination, also displayed significant difference between the two groups(P<0.05).

CONCLUSION: Binocular visual function training has a certain effect in the improvement of successful cure rate, shortening treatment course and establishing a sound stereo vision function in the late stage of children patients receiving a comprehensive therapy.