Retinal vein occlusion(RVO)is the most prevalent retinal vascular disease except for diabetic retinopathy. Macular edema(ME)is a common complication of RVO which is the major causation of vision loss. The pathogenesis of ME is associated with vascular endothelial growth factor(VEGF)which induced by ischemia and hypoxia after venous obstruction and destruction of blood-retinal barrier caused by inflammation. Therefore, intravitreal injection of anti-VEGF medications or corticosteroids is the most common in the clinical treatment. Due to the two medicines have different react mechanism, duration of efficacy, side effects, and prices etc. There are several researches reported that the combination of two medications in order to treat ME secondary to RVO. This essay is a brief overview of the combination therapies' efficacy, the time of injections and relevant precautions during the therapy process.